Lost

Lost starts with no health and cannot gain health in any way. Therefore, taking damage will kill him.

• Lost starts with flying.

3DS Lost also starts with D4 (if unlocked).

• Lost starts with flying, spectral tears, D4 (if unlocked), and the effects of the Sacred Robe (after donating 879 coins to the Greed Donation Machine).
• Missed starts with flying, mysterious tears, D6 of eternity, and the effects of the Sacred Cloak (after donating 879 coins to the Greed Donation Machine). This Sacred Cloak is not a starting item, but is unique to that character, so it is present when you switch to Lost midway using the clicker, and not present when you switch back, and cannot be removed in any way.

Lost is in Greed mode, where he can activate the button without taking damage in exchange for less coins in the next wave's reward.

Losers can receive Devil's Deal and Black Market items for free.

• Devil's Deal and Black Market items are presented as options. Taking one will frustrate all other offers in the room.
  • This also applies to the demon offerings in the first dark room. You can only take one of the chest-crafted demon offerings, no matter how many chests you open.

  Contents

  • 1 Notes
  • 2 General Strategy
  • 3 Element Interactions
  • 4 Unlocking Lost in Afterbirth
  • 5 Unlocking Lost in Afterbirth
    • 5. 1 Notes on unlocking Lost
    • 5. 2 File Handling
    • 5. 3 Seeds that help with regeneration
      • 5. 3. 1 Isaac
      • 5. 3. 2 Maggie
      • 5. 3. 3 Judas
      • 5. 3. 4 Azazel
      • 5. 3. 5 Lost

      Notes ❶ ].

      • Resurrection items like Dead Cats are invaluable to the Lost.
      • Trade with demons while they're free, again counting trades with demons to keep the angel room from opening. Therefore, obtaining credit cards or chaos is recommended to obtain angel items (except broken key fragments).
      • Using IV bags or blood donation machines will instantly kill the loser even if they have a holy garment.
      • Bedrooms are much more common, such as those lost due to lack of health. While they may not benefit from the healing provided by a bed, the guaranteed crawl space of a clean bedroom can increase the chance of obtaining items.
      • If Lost's Holy Mantle effect is lost within a cursed room, quitting and starting the game, then continuing the run will restore the Holy Mantle class, and Lost can leave the room as it is.
        • Losers can no longer recover their Holy Mantle by quitting the game, starting a game, and continuing the run.
        • Breaking the Holy Mantle grants a frame of invincibility for 1 second, regardless of the cause of the damage.
        • Lost's Holy Mantle is not native, so Lost's Victory Lap will always die on hit unless the player has specifically found the Holy Mantle.
        • Getting hit by another Holy Mantle does not double the effect.
        • This Holy Mantle's effect is unique, so it does not appear in the pause menu.
        • Make items free with credit cards, coupons, and Mr. ME! .
        • Clone items with Diplopias or Crooked Penny (you can get all cloned items, but the original item appears as an option).
        • Make items purchased with pennies using Keeper's Bargain, Strawman, and A Pound of Flesh.
        • Souls can be used to acquire items.

        Common Strategies [ | ].

        Main Articles
        • One of the biggest problems with having no health is that many items become completely useless. Items that only give health, only have an effect after taking damage, or items that cost health to use are of no benefit in The Lost.
          • This is mitigated by the Eternal D6, which appears at the beginning of The Lost. Eternal D6 has a chance to destroy the item instead of rewinding it, which is not bad if used on useless items. In fact, by itself it can only have a net positive effect (such as rewinding a useless item into a useful one) or a neutral effect such as creating or destroying another useless item.

          About item interactions [ | ]

          • Alabaster Box Soul Heart works as expected.
          • Birthright : Prevents items with the nolostbr tag from being played inside it. In practice, most items that are not beneficial in The Lost are automatically reset, especially those that only grant health, flight, and/or spectral tear, or those that activate when damaged.
          • Fragile Bones : Upon receiving this item, the Lost receives a one-time bonus of +0, 5 Tears (+0, 4 Fire Rate). This bonus is maintained even if the item is later lost or recirculated.
          • Habits : Holy Mantle does not trigger Habit effects, making it nearly useless. The only way to trigger the effect is to take damage, which will effectively kill the Lost or cost them an extra life. The same goes for items that require damage.
          • Heartbreak : The Lost receives the full benefit of the item. This allows them to survive 4 additional attacks, each dealing 1 damage, with the fifth being fatal.
          • Whore of Babylon: Since The Lost has no red hearts (though he does have half a soul heart), Whore of Babylon is always in effect, effectively transforming his damage and accelerating his upgrades.

          Unlock The Lost in Afterbirth ❶ ].

          The Lost is unlocked by dying while holding a missing poster in the Sacrifice Room.

          • To unlock The Lost, you must unlock the Missing Poster.
          • The Missing Poster is unlocked by killing the Lamb as Isaac.
          • Searching the Mama Boxes in the shop makes it easier to find the posters.
          • Glyph of Balance: If all of the conditions are met, the room clear reward changes, causing champions to drop trinkets while not holding them, greatly increasing the chance of finding the missing poster.
          • Glitter Bombs, when combined with a large enough bomb source or a bomb source with insufficient experience (such as Gold Bombs), have a smaller chance of dropping trinkets, making it easier to find the posters.
            • This method has been nerfed: Glitter Bombs are now capped in drops per floor.
            • Sacrificing health 12 or more times in a row has a 50% chance of teleporting to a dark room. Make sure Isaac has no more than 11 hearts before attempting to die in the sacrifice room.
            • The sixth health sacrifice in the series has a 33% chance of teleporting Isaac to the angel room. If Isaac misses the final sacrifice and teleports to the angel room, the Loser will not be unlocked.
            • Deing on spikes in particular is not necessary to unlock the Loser, so it is recommended to use other damage sources such as bombs in these cases.

            Regenerate to unlock Lost ❶ ].

            Lost is unlocked from death 4 times in a row by certain characters dying on certain occasions. Deaths must be completed sequentially in the order listed below. Seeds can be used in all but the last step.

            1. Isaac must die in Maliboom in Chapter 1.
            2. Magdalene must die in Maliboom in Chapter 2.
            3. Judas must die in Mama. Being killed by a monster born from Mama will ruin the entire attempt at revival.
            4. Finally, Azazel must die to Satan. Being killed by Satan or any other enemy born from the Fallen will ruin the entire attempt to free the Losers. Using the Bible on Satan does not count towards your death by Satan. Additionally, you cannot be killed by Satan's trample in phase 3. You must die in Satan's second phase.

            Lost is unlocked after completing the steps above.

            Notes on unlocking Lost ❶ ].

            • Multiple lives (for example, the life obtained by dead cat) must be fulfilled before they die.
            • It is strongly recommended that you do not bring items and equipment that may be resurrected after death, such as GUPPY COLLAR and BROKEN ANKH.
            • If you install a mod that enables the mod flag, you will not be able to get the Lost. To solve this problem, you need to delete all mods.
            • You can't play games because any character needs to unlock at the time of unlock.
            • Champion version monsters and bosses are counted as death standards.
            • Execution can reset at any time.
            • Since MOM'S FOOT trampling is counted as an explosion damage, pyromaniac is a problematic choice when trying to clear Step 3.
            • Even if you choose a wrong character during unlocking, the unlock process will not be confusing. [1]
            • The unlock process will not break even if you stop the game in the middle of the unlock process and restart it. [1]
            • You should avoid picking up Lazaro's cloth, the shadow of Judas, and Ankh. These items will not achieve the current unlock step because the current character will be revived as another person.
            • Exploit: If you die in the necessary path, press the "Start" button at the same time as the death, and r e-pawn before the Isaac will appear, it will not be considered to have died in the way. It is counted as a restart instead.

            Handling of files

            By changing the file parameter, you can cancel the failed trial:

            1. Copy the options. ini file in the Binding of ISAAC Rebirth of Documentsmy Games to the same folder and back up.

            Open the original file in a notepad and change the SteamCloud parameters to 0. This will disable Steam Cloud Game Synchronization.

            1. If the trial fails, delete the original file and change the backup file name to Options. ini as the original file name.
            2. Repeat steps 1 every time you succeed until you unlock the Lost.
            3. When you're done, open the original file and reset the SteamCloud parameters to 1. This will enable Steam Cloud Game Synchronization again.

            Seeds useful for regeneration ❶].

            Isac

            PC GPE3 2T1H (2 maliboom south of the starting point. Sel f-harm in the Sakurifice Room above)

            PC PS4 JTMD EZPF (Maliboom just below the start point. First, go to the left and weaken yourself)

            PC 4Z93 R21B (Maliboom is one below the starting point)

            PC GH9Y FSA8 (Row of rooms including maliboom going down)

            PC Q2V4 YZET (It is necessary to unlock the basement, 2x2 room, full of maribuum (about 6/7))

            Vita GQHN NMKN (to the left, 4 or more mary)

            3DS 6Z2L AZ6J (to left, 4 or more maliboom)

            3DS VNSM AHG (Go up, weaken with spikes, go up, die in mary)

            3DS PXRT XH49 (climbing and weakening on the lawn в†’ Detailed and died in mary)

            iOS 3KY7 JPBJ (After going to the right and weakening, going to the left has two maliboom)

            melancholic

            PC ALFA 0 NTS (Difficulty Normal Recommended, Pyro in the first treasure house, then overlaps)

            PS4 FDRG 0CTE (Pyro in the first treasure house, next duplicate)

            Vita DXVW MQCF (Pyro in the first treasure house)

            3DS YGDC T8SL (10 bombs in the first treasure house)

            iOS E1NZ N3MA (there is a bomb in the shop on the second floor.)

            Juda

            PC YR8E YXDV (It is often seen in the first treasure house. In the angel room, you can get Trinity Shield and Sacred Heart, so do not take the devil's offerings. To ensure that you have a Belial book to make it appear. (The first boss, the duke of the fly) is taken in the order of orange (improving physical strength) в†’ blue (quick down).

            PC N0G3 VLD4 (both) -Dr. Fetus on the first floor, IPECAC on the second floor.

            PS4 DMTM NRD9 (If you do not sign a devil room in the basement II, you will have an angel room with a holy grail in Cave I. Collect all the granted tears.

            3DS 180Y 7rdc (a lot of physical strength in the early stages (wheels in the first treasure house), good pic k-up (Marigan is the second treasure house, Dr. Fettal and Mega is the third and fourth)). Hip, scapula.

            iOS 0fp1 C9JK (Heart in the first boss room, you can get dead cat in the first Devil Deal and survive)

            Azazel

            Using seeds in this step is not counted in Lost One unlock.

            Lost

            PC HNA6 WEK7 (Get Dead Cat and Holy Mantle on 1F. Convenient for practical routes)

            PC616S Grog (Holy Mantle on the right on the spawn)

            

            Elim Rim - Journalist, creative writer

            Last modified 11.03.2025

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